Current DHHS Treatment Guidelines
For First Time Therapy

Clinicians are recommended to construct an initial regimen (for first time therapy) by choosing one component from Column A plus one component from Column B*
  Column A Column B
NNRTI PI
Preferred (alphabetical order)
Efavirenz 1 Atazanavir + ritonavir (once daily)
Fosamprenavir + ritonavir (twice daily)
Darunavir + ritonavir (once daily)
Lopinavir/ritonavir (once or twice daily)

Tenofovir/emtricitabine 3

 
Alternative (alphabetical order)
Nevirapine 2 Atazanavir 4 (unboosted, once daily)
Fosamprenavir (unboosted, twice daily)
Fosamprenavir + ritonavir (once daily)
Saquinavir + ritonavir (twice daily)

Abacavir/lamivudine 3
Didanosine + lamivudine 3
Zidovudine/lamivudine 3
  1. Except during first trimester of pregnancy or in women with high pregnancy potential
  2. Nevirapine should not be initiated in women with CD4+ T-cell count greater than 250 cells/mm3 or in men with CD4+ T-cell count greater than 400 cells/mm3
  3. Emtricitabine and lamivudine are interchangeable
  4. Atazanavir must be boosted with ritonavir if used in combination with tenofovir.

Editor’s note: Above drug names are generic. Please refer to the individual drug pages for brand names, or visit www.tpan.com.

* Panel on Antiretroviral Guidelines for Adult and Adolescents. Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. Department of Health and Human Services. November 3, 2008; 1–136. Available at http://www.aidsinfo.nih.gov. Accessed January 21, 2009; page 38, Table 6.

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